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March 2026: Novo Nordisk reported top-line REDEFINE-1 Phase 3 CagriSema data showing 22.7% mean body weight reduction at 52 weeks , demonstrating superiority over standalone semaglutide 2.4mg and confirming the semaglutide-plus-amylin combination as clinically competitive with tirzepatide

This demonstrates that whole-body glucose homeostasis is tightly linked to insulin-mediated control of glucose transport and metabolism in adipocytes

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(Berlin: Springer), 137152

Company-affiliated authors - The study was authored by Ivim Health employees, which does not invalidate the research but is a conflict of interest you should be aware of