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[5] Through gene regulation, estradiol promotes vaginal epithelial maturation, supports collagen synthesis within skin, and contributes to nitric-oxide-mediated vasodilation, collectively providing mechanistic explanations for clinical benefits such as improved vulvovaginal comfort and reduction in hot-flash frequency

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Milk thistle, while generally safe, may affect how the liver processes certain medications always check with your pharmacist or doctor before combining

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Hunter HN, Fulton DB, Ganz T, Vogel HJ: The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis