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Developer: Eli Lilly and Company | Administration in Trials: Once-weekly subcutaneous injection First successful Phase 3 trial (TRIUMPH-4, topline Dec 2025): Up to 28.7% average body weight loss at 68 weeks (highest dose) in adults with obesity/overweight and knee osteoarthritis

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14 Long-term studies and postmarketing data may help answer this question

GLP-1 medications have emerged as a powerful tool for weight loss, but access and affordability remain significant barriers

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Juan Frias, Medical Director of the National Research Institute in Los Angeles, discussed tirzepatide, a dual GIP/GLP-1 under investigation for people with obesity resulting in significant weight loss