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Despite the widespread use of serotonergic medications, benzodiazepines and cognitive behavioral therapy (CBT), therapeutic outcomes remain limited with less than 50% of patients reaching full remission and nearly one-third do not respond to conventional treatments (De Vries et al., 2016)

10.1111/imr.13235 40 TianP.XuZ.GuoJ.ZhaoJ.ChenW.HuangW.et al (2024)

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In the external modification of bacteria, the chemical coupling strategy based on covalent bonds can stably and irreversibly link functional molecules to the bacterial surface through specific chemical reactions [116]

This is because after this period, the bacteriostatic preservative can no longer prevent contamination, often leading to a compromised product that can put the patients at risk