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The phase 3 REDEFINE program, published in The New England Journal of Medicine and presented at the American Diabetes Associations Scientific Sessions in June 2025, put the combination to the test

The ampoule should only be opened and drawn into the syringe immediately before use to maintain its potency

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Its small molecular weight (~505 Da) and lipophilic character support oral capsule administration consistent with the published research literature

For patients with neurological complications, more intensive treatment is required (1 mg on alternate days until no further improvement, followed by 1 mg every 2 months)

For the pre-bed option, the last meal of the evening should be finished well before the dose