Semaglutide works by: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces hepatic glucose production Slowing gastric emptying , leading to reduced appetite and food intake Acting on appetite centres in the brain , promoting satiety These combined effects result in improved blood glucose control and, as a secondary benefit, significant weight loss in many patients
People who discontinue GLP-1 drugs usually put the weight back on, and most experts believe that the medications need to be used indefinitely in order to deliver sustainable benefits
By limiting the transport of these molecules to the cell membrane, H 2 decreases NADPH oxidase activity, reduces the generation of ROS, and ultimately achieves an antioxidant effect
In addition to appetite control, semaglutide improves insulin sensitivity and helps regulate blood sugar levels
Fathi E, Farahzadi R, Charoudeh HN
N Engl J Med 2003
