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Baseline and periodic IGF-I , fasting glucose/HbA1c, lipids, liver function tests, and clinician-directed screening are typical

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Storing peptides in plastic syringes can lead to degradation and adherence of the peptide to the plastic over time, affecting the dose accuracy

In this way, it serves as a proofofconcept that even a peptide or protein drug known to have poor bioavailability can still be delivered orally, and without any modification, if we compensate by delivering a sufficiently high dose

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