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When l-aspartate-semialdehyde (ASA) concentrations were varied using NADPH as a cofactor, the k cat and K m of Pa DHDPR were 52 1.1 s 1 and 12 1.6 M, respectively (Supplementary Table S1)

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Metformin-related vitamin B12 deficiency occurs as metformin causes reduced vitamin B12 absorption by interfering with the vitamin B12-intrinsic factor complex