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Sharpe, Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food

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This cohort comprised 45 participants in the 3 mg group, 92 participants in the 7 mg group, and 32 participants in the 14 mg group, respectively ( Figure 1 )

Late-day dosing causes insomnia, which is already a concern with the CNS stimulation this drug produces

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It fragments into unpredictable breakdown products that mass spectrometry will detect as impurities