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Adverse events with gastrointestinal symptoms were observed in 37.1%43.6% of patients in the tirzepatide group and 20.4% of patients in the placebo cohort

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In summary, FOXO4-DRI exerts its anti-aging effects by inhibiting the binding of FOXO4 to P53, promoting P53 phosphorylation, and facilitating the translocation of p-P53 from the nucleus to the cytoplasm for its functional role