The starting dose is designed for tolerance assessment, not therapeutic effect
Originally developed to manage type 2 diabetes, Semaglutide gained FDA approval in 2021 for use as a weight loss treatment
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That is 30% to 50% below the recommended range for muscle preservation during weight loss
By 104 weeks, approximately 77% of SELECT patients on dose were receiving the target semaglutide 2.4 mg weekly dose, which is lower than the corresponding proportion of patients in STEP 1 (89.6% were receiving the target dose at week 68) 14,21
At 2.5mg/mL concentration, that is 0.35-0.6mg of semaglutide you paid for but never received