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PPAR- as a nuclear hormone receptor is responsible for lipid metabolism by inducing mitochondrial fatty acid -oxidation and directly upregulates OCTN-2 expression and increases l-carnitine uptake via OCTN-2 in liver

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Early studies suggested that anthranoid laxatives might have carcinogenic or tumor-promoting activities in humans and that the presence of melanosis coli might signal an increased risk for the development of colorectal cancer