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34 Increased adipocyte leptin content and high circulating leptin levels are usually in the obese, which has led to the suggestion of leptin resistance

Yes, blood tests may be conducted to monitor potassium levels, as Spironolactone can cause mild elevations in potassium

doi: 10.3389/FCELL.2022.1104326 132

The same data also showed an 11% decrease in insulin resistance

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Heckman MA, Weil J, De Gonzalez E (2010) Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters