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The researchers didnt find such an association in women, and it was mostly seen among men who smoked

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Higher doses reaching up to 3x250mcg/daily have been reported anecdotally [45, 46]

Storing a vial on its side or inverted keeps the solution in sustained contact with the rubber stopper, which pharmaceutical literature describes as a potential leachable-contamination pathway over extended periods

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PubChem Compound Summary for CID 56841945