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Inside the white puff envelope, we found the ice block, a plastic bag, a paper thank you bag with the prescription label stapled to it, and the medication inside a small bubble-pop envelope

Depletion of Tregs in mice has been associated with increased anxiety-like behaviors and elevated levels of inflammatory cytokines, suggesting that Tregs may help attenuate the effects of neuroinflammation on mood [173,179]

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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics

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Elashoff M, et al