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Broader clinical trial data suggests that approximately 10% of patients across all indications and doses may discontinue semaglutide due to GI complaints, which is comparable to or slightly higher than other GLP-1 receptor agonists

These are generally most pronounced during the dose titration phase and tend to diminish as the body adjusts to treatment

10.1002/ana.410280106 149 RothsteinJ

Acknowledgments The authors thank the co-workers of the Institute of Animal Nutrition and the co-workers of the experimental station of the Friedrich-Loeffler-Institut in Braunschweig for their great support, as well as all other members of the MitoCow team

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Can, for example, a direct effect be mediated by glucagon receptors on L-cells