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Kim MK, Suh GA, Cullen GD, Rodriguez SP, Dharmaraj T, Chang THW, et al

(Lausanne) 10:704

Clinical and experimental reproductive medicine

10.1002/emmm.200900006 EMBO Mol

As random effects, we had intercepts for plateID (replicates), as well as by-plateID random slopes for the effect of time

Replacing the sulfonic acid at position R 1 with a sulfonamide group ( 33 ) resulted in a drastic decrease in solubility of the fragment with a concomitant reduction of binding to TRF1 TRFH by CPMG, whilst the dimethyl sulfonamide 35 or the even bigger benzyl sulfonamide 36 showed an even poorer solubility and a loss of TRF1 TRFH binding (Table 1)