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In 2-year rat carcinogenicity studies referenced in the Increlex label, increased mammary and skin tumor incidence occurred at high IGF-1 exposure

I., Yang S

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The review traced foundational work demonstrating that protein glutathionylation occurs in response to both oxidative stress and hormonal stimulation, confirming it as a major mechanism of redox-regulated signal transduction

Labunets IF, Butenko GM, Khavinson VK