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A meta-analysis of 76 trials showed a 37% higher risk of gallbladder and biliary disorders with GLP-1 agonists, especially at higher doses or for weight loss

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3 In general, this GLP-1 agonist has been shown to have effects on -cell proliferation and neognesis, inhibition of apoptosis (programmed cell death), cellular stress reduction, and insulin transcription, synthesis, and secretion