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It was found that the BICD2 gene in the peripheral blood of MDD patients and depressed mice showed DNA hypermethylation and mRNA downregulation, while the BICD2 gene in the hippocampus of depressed mice showed DNA hypomethylation and mRNA and protein up-regulation, and the BICD2 protein was also up-regulated in the hippocampus of MDD patients after death

doi: 10.1111/cen.14189 54 BauerMWhybrowPC

People with Liver Disease: Because berberine impacts liver enzymes, those with pre-existing liver conditions should be extremely cautious

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As oxidative stress increases, glutathione is used as an antioxidant, and active GSH gets depleted