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Hepatic dysfunction is described in patients during episodes of metabolic derangement [28] and can be fatal

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EASL clinical practice guidelines: management of hepatocellular carcinoma

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Pathophysiological mechanisms of HE HE occurs due to a combination of distinct pathophysiological mechanisms such as inflammation [32], oxidative stress [33], impaired bloodbrain barrier (BBB) permeability, neurotoxins, impaired energy metabolism of the brain [34] and more (Fig

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