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A large comparative-effectiveness study published in JAMA Internal Medicine analyzed approximately 36,000 patients on SGLT2 inhibitors versus 19,000 on GLP-1 receptor agonists in Denmark (Jensen et al., 2026)

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DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA

doi: 10.1111/j.1523-1755.2005.09421.x 193 BorgesFTMeloSAzdemirBCKatoNRevueltaIMillerCAet al

Although many patients achieve their LDL cholesterol target concentration with monotherapy using appropriate doses, a large proportion of high-risk and very high-risk patients, or those with markedly elevated LDL-C concentration, require additional treatment

This is true even though they are losing some muscle mass alongside body fat