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5a) led to a decrease in the expression of GPX4 in a time- and concentration-dependent manner, and a cumulative effect was observed when using fluvastatin and RSL3, showing that both contribute to ferroptosis

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This is likely due to the more established CKD-specific evidence base available for SGLT2is [10,11,12], and the fact that FLOW evaluated semaglutide in patients receiving prior guideline-directed standard of care, limiting generalisability to GLP-1 RAs more broadly as a first-line therapy [8, 9]

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After removing duplicate papers and screening the articles carefully by the title and abstract, thirty-five papers were included

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