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But a number in the safety data spooked a few of us that were paying extra attention to the details: Dysesthesia occurred in 20.9% of participants on the 12 mg dose

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289,290 Survodutide is a novel dual glucagon receptor and GLP-1 receptor agonist.291 In phase 2 trials, it conferred significant weight loss (up to 19% of total body weight) in people with obesity without type 2 diabetes

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Zannad F, Ferreira JP, Pocock SJ, Anker SD, Butler J, Filippatos G, et al

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However, the dosage can be tricky, as too much can cause unwanted side effects like euphoria or jitteriness

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