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Laboratory studies have demonstrated biological activity at concentrations as low as 0.01 nanomolar, showing measurable effects on fibroblast activity and collagen production even at these minute levels

10 who had undergone surgery but had no symptoms

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Actually, this is not strictly true because there are two relatively small other drains of mass in the methionine cycle, the polyamine drain from SAM and the thiolactone drain from Hcy

The medication already creates significant restriction