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(STEP 4) Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial JAMA 325(14) 2021PMID: 33755728 PubMed References open in a new tab

0.5 mL of medium was removed from each well, and replaced with medium containing (i) FITC-insulin alone (concentration 100 L/mL), (ii) FITC-insulin with sodium chenodeoxycholate (1 mg/mL) or (iii) FITC-insulin with sodium chenodeoxycholate (2 mg/mL)

Insulin resistance and insulin sensitizing agents

At the mechanistic level, IDH mutations lead to the NADPH-dependent production of the oncometabolite D-2-hydroxyglutarate (D-2HG) from KG [77]

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