Applications in ObesityRelated Pathological Mechanism Research Advancing Research on the Pathogenesis of NonAlcoholic Fatty Liver Disease Nonalcoholic fatty liver disease is another major obesityrelated complication, marked by excessive hepatic fat accumulation, which can progress to cirrhosis and liver cancer in severe cases
In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
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