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The glucagon factor (carbs are not the enemy) glucagon receptor

Permanent discontinuation of treatment as a result of a gastrointestinal adverse reaction occurred in 4.3% of WEGOVY-treated adult patients versus 0.7% of placebo-treated patients

Based on raw numbers, the NNT is 1 / (0.3*0.01) = 333 but adjusted the NTT is approximately 1 / (0.57*0.4*0.01) = 438

As recently described in a brief communication in Gastroenterology , these patients surprisingly experienced complete remission of their bile acid diarrhea, in addition to the expected glucose- and body weight-lowering effects of liraglutide

95% CI 1.53 to 18.63

2004, 287: L774-L783