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Why Addressing the Nervous System Is Essential If the nervous system is not addressed, pain may: Spread beyond the original injury site Return quickly after medications wear off Worsen during stress or fatigue Become resistant to escalating interventions This helps explain why chronic pain frequently persists despite normal imaging, laboratory results, or repeated structural treatments

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These findings highlight the intricate interplay between mechanosensitive and heat-sensitive channels in the PNS and CNS, suggesting Piezo2 as a potential therapeutic target for visceral pain treatment

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