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The complex travels through the small intestine until it reaches the terminal ileum, where specialised receptors called cubam (a complex of cubilin and amnionless proteins) recognise and facilitate the uptake of the B12-IF complex into enterocytes (intestinal cells)

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It is an effective precursor for NAD+, but it comes with a well-known side effect: the niacin flush, which causes uncomfortable skin redness and itching

While the new information from the preliminary findings of the 19-patient clinical trial currently underway may address our concern about the lack of human clinical trial evidence, we believe that the data provided does not sufficiently demonstrate substantial clinical improvement