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Code availability The codebase is available at Funding This work was funded by Breakthrough T1D (2-SRA-2022-1200-S-B: SyneRegIm: exploring the SYNErgistic effect of beta cell REGeneration and emerging IMmune intervention strategies to prevent and/or reverse type 1 diabetes)

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In that regard, the transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) and its main negative regulator KEAP1 (Kelch-like ECH (erythroid cell-derived protein with CNC homology)-associated protein 1) represent a finely regulated antioxidant system, with a key role in the response to OS and maintenance of redox homeostasis