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Limitations: Animal models only

Intermittent fasting promotes adipocyte mitochondrial fusion through Sirt3-mediated deacetylation of Mdh2

The FLOW trial, which studied semaglutide in people with diabetes and chronic kidney disease, found that semaglutide reduced the risk of kidney disease progression and kidney-related death

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The ROR metric serves as a quantitative indicator of the strength of association between the target drug and specific adverse events (AEs), with elevated ROR values denoting stronger statistical associations