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Some PK studies report an increased theoretical risk of toxicity with advancing age [62,63,64,65,66,67] due to prolongation of t 1/2 [62, 63], reduced paracetamol clearance [64, 67], increased paracetamol oxidation caused by a reduction in glucuronidation and sulphation capacity [65] or a reduction in liver volume [66]

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FABP4, a member of the FABP family and an essential lipid chaperone, has been identified as a key protein involved in facilitating intracellular FA uptake and targeted localization [291]