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Some samples contained none of the labeled compound

Exenatide had the smallest effect across all of the data analyzed, though it still showed an association with reduced amyloid-beta and tau in some studies

Kopp KO, Glotfelty EJ, Li Y, Greig NH (2022) Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: implications for neurodegenerative disease treatment

Here, too, the evidence is lopsided

Preserved incretin activity of glucagon-like peptide 1[7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

Together, these changes contribute to thinning, laxity, uneven texture, and the appearance of wrinkles