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It then passes through the atrioventricular (AV) node and triggers the ventricles to contract, which having just been filled with blood by the contracting atria, pump blood out to the rest of the body (Patterson 2002)

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Together, molecular clocks, neural circuits, and hormonal signals form an integrated neuroendocrinecircadian axis that coordinates physiological homeostasis and modulates stress responses

Butyrate, a type of SCFA, serves as an energy source for IECs, improves villus structure, enhances intestinal elasticity, and increases the absorptive surface area, hence promoting calcium absorption