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Abnormal keratinocyte phagocytosis has been demonstrated resulting in reduced transfer of melanin from melanocytes

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(Bethesda) 31 , 283293 (2016)

Bedwell, S., Deant, R

This process apparently starts when the VEGF protein, which is considered to be secreted by oxygen-deprived cells during a hypoxic response, and may bind to VEGF receptors on the surface of endothelial cells

The included trials were those with administration of recombinant semaglutide in which PK samples, assessed via liquid chromatography and tandem mass spectrometry (LCMS/MS) [3], were available at the time of the analysis