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Interestingly, single alanine amino acid substitutions of some interacting residues within the TMD had much larger effects on exendin-4 affinity than removal of the first 8 residues of the peptide (exendin (939) 22,31 ), suggesting that peptide ECD and TMD interactions are correlated

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SURMOUNT-1 tested the dual GLP-1/GIP agonist tirzepatide in adults without diabetes over 72 weeks