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Emphasis is placed on clinical screening, controlled titration, and ongoing monitoring to align outcomes with safety parameters

Discussion It was unclear whether GLP-1 analogs are effective in models lacking the MC4R pathway

During injection, patients commonly report feeling: A brief pinch as the needle enters the skin Mild pressure as the medication is delivered (typically 5-10 seconds) Occasional slight burning or stinging sensation Minimal to no pain after needle withdrawal The anticipation of pain is often worse than the actual experience

DECLARATIONS Acknowledgements The authors thank all participants and investigators involved in this study

Understanding these differences is key for patients