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The liver also plays a role in storing vitamin B12, and liver diseases could affect B12 storage and lead to deficiency

The decision to escalate from 8mg to 12mg depends on individual response, tolerability, and research objectives

Patients who skip the break period and run continuous cycles do not get proportionally better outcomes and risk diminishing returns on the therapeutic response

Concentration differences from compounding pharmacies Compounding pharmacies may use concentrations that differ from the standard research-grade options

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Intramuscular (IM): Less common but sometimes used for deep tissue or joint injuries