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Mechanistic studies have established that Dihexas procognitive and synaptogenic effects are mediated by the hepatocyte growth factor (HGF) / c-Met receptor system rather than by the classical AT 4 receptor, despite Dihexas structural origin as an angiotensin IV derivative

10.1016/j.diabet.2018.03.004 Diabetes Metab

Alterations in the phosphorylation and glycosylation status of OCTN2 may also contribute to this process [106, 107]

5 Possible Causes (Updated: February 17, 2025)

596 Notably, memory loss in the PS2APP mouse AD model has been linked to astrocyte Ca 2+ hypoactivity due to reduced expression by astrocytes of the calcium sensor, STIM1

Poole P, Sathananthan K, Fortescue R