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This change happened after Judge Gene E.K

In the efficacy study with obese monkeys, the dosing regimen that produced the 11% body weight loss and 39% fat deposit reduction over 28 days was not precisely detailed in all publications, but researchers described managing doses to balance efficacy against renal function

While you can take it at any time to maintain general levels, research suggests that the best time to take it is when your insulin levels are elevated

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