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Moreover, existing data indicate that single-target GLP-1RAs such as SEMA and liraglutide show promising capabilities for fibrosis improvement, and the initial success of the dual agonist tirzepatide suggests potential benefits of dose titration therapy in the monotherapy management of MASLD
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Clinically meaningful body weight reductions were observed, with petrelintide achieving up to -8.6% weight loss compared to -1.7% with placebo after 16 weeks
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DOI: 10.1054/mehy.2000.1169 Traish, A.M., et al
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