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Continuous, uninterrupted GHRH stimulation leads to receptor downregulation over time, reducing the efficacy of the peptide

Author contributions NN carried out the experiments, data, and statistical analysis, and wrote the manuscript

Gastrointestinal issues are the most common, but some patients report changes in appetite suppression, energy levels, or digestive tolerance when moving from semaglutide to tirzepatide

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The average follow-up time with participants was 39.8 months, and the average time participants took semaglutide was 34.2 months