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Copper(II) peptide complexes are photolabile and prolonged UV or fluorescent exposure can drive ligand oxidation

10.1016/j.ejmech.2024.116674 117 TuoQ

Others propose that liposomes perform the function of penetration enhancers because when applied onto the skin, they break down the cell membranes and diffuse as a lipid mixture

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As scientists learned more about amylin biology, they began testing modified analogs

No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate