doi: 10.1186/s12885-021-08721-8 17
La GLP-1 natural es degradada rpidamente por la enzima DPP-4 en minutos, mientras que los agonistas de GLP-1 son anlogos sintticos diseados para resistir esta degradacin, permitiendo una accin prolongada
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This eliminates confounding from intensive lifestyle enrichment (STEP 3, SURMOUNT-3) and run-in/maintenance designs (STEP 4, SURMOUNT-4) that inflate active-arm weight loss estimates
GLP-1 drugs are at the center of this transition, acting as a bridge between traditional metabolic care and newer, more patient-driven models
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