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SGLT2-I reduces oxidative stress by translocating Nrf2 to the nucleus and triggering Nrf2/ARE signaling, which lessens myocardial fibrosis by inhibiting collagen deposition through the traditional TGF-/Smad pathway [41]

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Whilst generally well-tolerated, it can cause gastrointestinal side effects (steatorrhoea, faecal urgency) that may be problematic in Crohn's disease

Mast cells, a type of granulocyte, contain chemicals needed in the bodys immune response

95% CI 0.66, 0.75)

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