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Electroencephalograms (EEGs) in patients with MELAS typically show diffuse background slowing, often accompanied by slow waves mixed with sharp waves, especially in the bilateral anterior regions (28)

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They separate toxic compounds, drugs, and metabolic waste products like ammonia and urea, preparing them for excretion

The onset of the disease is associated with massive dystrophy and death of astrocytes, which directly correlate to the severity of the disease

These preclinical studies indicated that dysfunctional SIRT1 is associated with PD pathogenesis

The kinase activity of nuclear IGF-1R is also implicated in the phosphorylation of histone H3, recruitment of the ATP-dependent helicase Brg1 and the expression of SNAI2 [118], which in turn is involved in cell migration and epithelial-mesenchymal transformation