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Females taking GLP-1 medications had about 35% lower odds of developing breast cancer compared to those who did not use these drugs in the full cohort

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These include hormonal dysregulation, chronic inflammation, altered adipokine signaling, insulin resistance, and activation of oncogenic intracellular pathways that collectively promote tumor progression, metastasis, and therapy resistance [4,20]

Additionally, aryl hydrocarbon receptor (AHR) activation during renal tubular epithelial cell reoxygenation induces ROS production, lipid peroxidation, and ferroptosis via AHR-mediated CYP enzyme overexpression, identifying AHR as another potential therapeutic target (81)

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Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat