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Koeth Robert A., Wang Zeneng, Levison Bruce S., Buffa Jennifer A., Org Elin, Sheehy Brendan T., Britt Earl B., Fu Xiaoming, Wu Yuping, Li Lin, Smith Jonathan D., DiDonato Joseph A., Chen Jun, Li Hongzhe, Wu Gary D., Lewis James D., Warrier Manya,Brown J
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References: Anderson, J.W., Greenway, F.L., Fujioka, K., Gadde, K.M., McKenney, J
Weight that remains unresponsive to traditional diet and exercise alone
Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential
The evidence is real but modest: trial data shows more fat loss than placebo over 12 weeks, not dramatic transformation
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