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While -tocopherol loses its antioxidant capacity upon neutralizing a free radical, other antioxidants like vitamin C can regenerate it

"Ingestion of -nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study." Geroscience

some protocols use up to 1000 mcg daily for more significant GI pathology

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Ruwhof C, Drexhage HA